Background: Percutaneous Coronary Intervention (PCI) has become one of the most widely utilized revascularization procedures for the management of coronary artery disease (CAD). Technological advancements in stent design, imaging modalities, antiplatelet therapy, and procedural techniques have significantly improved clinical outcomes. However, challenges related to restenosis, stent thrombosis, recurrent ischemic events, and long-term mortality continue to influence patient prognosis.

Objective: This study evaluates clinical outcomes following PCI, focusing on short-term and long-term cardiovascular outcomes, procedural success rates, complications, predictors of prognosis, and recent advancements in interventional cardiology.

Methods: A comprehensive review of contemporary literature and clinical evidence was conducted to assess procedural outcomes, survival rates, major adverse cardiovascular events (MACE), and quality-of-life improvements following PCI.

Results: PCI demonstrates high procedural success rates exceeding 95% in modern practice. Drug-eluting stents (DES), intravascular imaging, and optimized pharmacological therapy have substantially reduced restenosis and adverse cardiovascular outcomes. Early intervention is associated with improved survival, reduced myocardial damage, and enhanced quality of life.

Conclusion: PCI remains a cornerstone therapy for CAD. Advances in technology, pharmacotherapy, and patient selection have significantly improved clinical outcomes. Future developments involving artificial intelligence, precision cardiology, and bioresorbable technologies may further enhance patient prognosis.