Background: Dengue fever is one of the most important mosquito-borne viral diseases worldwide, posing a major public health challenge in tropical and subtropical regions. The disease is caused by four distinct dengue virus serotypes (DENV-1 to DENV-4) and is transmitted primarily by Aedes aegypti mosquitoes. Clinical manifestations range from asymptomatic infection and mild febrile illness to severe dengue characterized by plasma leakage, hemorrhage, shock, and organ dysfunction. Despite substantial progress in clinical management, dengue continues to contribute significantly to morbidity, mortality, and healthcare burden.

Objective: This review examines current approaches to dengue fever management and evaluates clinical outcomes associated with early diagnosis, supportive care, fluid management, monitoring strategies, and public health interventions.

Methods: A comprehensive review of clinical studies, international guidelines, epidemiological reports, and evidence-based management strategies was conducted to assess treatment approaches, prognostic indicators, and patient outcomes.

Results: Early recognition, careful fluid therapy, laboratory monitoring, and timely intervention significantly reduce complications and mortality. Most patients recover completely with appropriate supportive care; however, severe dengue remains associated with substantial morbidity and occasional mortality. Emerging diagnostic technologies, predictive biomarkers, vaccine development, and digital surveillance systems may further improve outcomes.

Conclusion: Effective dengue management requires early diagnosis, vigilant monitoring, evidence-based supportive care, and strong public health measures. Continued research and integrated healthcare strategies are essential for reducing disease burden and improving clinical outcomes.