Coronary artery disease (CAD) remains one of the leading causes of mortality and morbidity worldwide, imposing a substantial burden on healthcare systems and economies. Although advances in medical therapy and interventional cardiology have improved outcomes, primary prevention remains the most effective strategy for reducing disease incidence. Lifestyle modification has emerged as a cornerstone of CAD prevention, targeting modifiable risk factors such as unhealthy diet, physical inactivity, tobacco use, obesity, hypertension, diabetes mellitus, and psychosocial stress. This study reviews the role of lifestyle interventions in preventing coronary artery disease and evaluates their impact on cardiovascular health outcomes. Through a comprehensive analysis of epidemiological studies, clinical trials, and international guidelines, the research highlights the effectiveness of dietary modification, regular physical activity, smoking cessation, weight management, stress reduction, and sleep optimization in reducing CAD risk. Findings demonstrate that sustained lifestyle changes significantly lower cardiovascular morbidity and mortality. The study concludes that integrating lifestyle medicine into clinical practice and public health policies is essential for combating the global burden of coronary artery disease.