Acute myocardial infarction (AMI) remains one of the leading causes of morbidity and mortality worldwide despite significant advances in cardiovascular care. Improvements in reperfusion therapies, pharmacological interventions, and secondary prevention strategies have substantially increased survival rates following AMI. However, many survivors continue to face long-term complications including recurrent cardiovascular events, heart failure, arrhythmias, reduced quality of life, and increased healthcare utilization. Understanding long-term outcomes after AMI is essential for optimizing patient management, improving survival, and enhancing quality of life. This review examines the epidemiology, determinants, clinical outcomes, risk factors, and management strategies associated with long-term survival after AMI. The study highlights the importance of comprehensive secondary prevention, lifestyle modification, cardiac rehabilitation, medication adherence, and emerging digital health technologies. Findings suggest that multidisciplinary follow-up care and personalized treatment approaches significantly improve long-term prognosis. Future research should focus on precision medicine, artificial intelligence-based risk prediction, and innovative interventions aimed at reducing cardiovascular morbidity among AMI survivors.