Background: Stroke is a leading cause of mortality and long-term disability worldwide, imposing significant clinical, social, and economic burdens. Effective stroke prevention strategies and comprehensive rehabilitation programs play critical roles in reducing stroke incidence, improving functional recovery, and enhancing quality of life among survivors. Advances in risk factor management, acute stroke care, neurorehabilitation technologies, and multidisciplinary rehabilitation approaches have significantly improved patient outcomes.

Objective: This review evaluates contemporary approaches to stroke prevention and rehabilitation, examining primary and secondary prevention strategies, rehabilitation interventions, clinical outcomes, and emerging innovations that influence recovery and long-term prognosis.

Methods: A narrative review of current literature, international guidelines, clinical trials, and rehabilitation studies was conducted to assess stroke prevention measures, rehabilitation effectiveness, functional outcomes, and future directions in stroke care.

Results: Effective management of modifiable risk factors such as hypertension, diabetes, atrial fibrillation, smoking, obesity, and dyslipidemia significantly reduces stroke incidence. Early multidisciplinary rehabilitation improves mobility, cognitive function, activities of daily living, and quality of life. Emerging technologies including robotics, artificial intelligence, virtual reality, telerehabilitation, and brain-computer interfaces show promising potential in enhancing recovery outcomes.

Conclusion: Stroke prevention and rehabilitation are integral components of comprehensive stroke care. Continued advancements in preventive medicine, personalized rehabilitation, and digital health technologies are expected to further improve survival, functional independence, and long-term outcomes among stroke survivors.